msp -
a given powder will run at higher pressures for jacketed bullets than for lead bullets of equal weight and similar bearing area. the jacketed bullets have a brinnell hardness of 100+ while the run-of-the-mill cast bullet runs in about 10 or so on the same scale.
PB is too fast for jacketed bullets, (PB means Porous Base) it's a shotgun powder, the standard trap or skeet load is 20.5 grains of PB with 1 1/8oz load. all the 280 loads i see in the IMR data book show the slower IMR powders, IMR4064, IMR4831,etc. slow burners !
i wouldn't use PB in a metallic center fire rifle round. save your PB for cast bullets, it's a good clean powder, cheap because the trap shooters used it in bulk.
the max load you mentioned should produce about 30,000 psi with a lead bullet with a gas check. at that pressure you are probably liquifying most of the rear of the bullet, how are the cast bullets shooting ? you need a brinnel hardness of about 20 ! or so for that load to keep it accurate.
anyway, don't use jacketed bullet with the PB powder, you will probably get hurt and trash a handi in the process. we don't anyone hurt !
sg