I understand you are working up loads, and testing the accuracy and performance of certain variables.
My question would be what others have said already.
Are you just planning on punching paper at 50 yards or using the loads for hunting varmints?
If you are planning on hunting with the load, practice up to the longest distance you are going to hunt at.
Your lower power scope will be a limiting factor at the longer ranges on small targets. But many say that it is unethical or just wrong to shoot the handguns at longer ranges, ie:200,300 yards plus.
I tend to take a different view. If you are shooting a load that is capable of carrying enough velocity and energy out to those distances, and you are using a bullet that will still perform at those distances, and YOU PRACTICE AT THOSE DISTANCES WITH A REST THAT YOU WILL USE IN THE FIELD....................then rock on.
You are more ethical and responsible than the guy who takes his 270 rifle out 1 week before deer season, throws a couple rounds down range, then wings a deer at 50 yards and losses it.
JMHO
Kevin