Well, I was think'n, if the .270 kills deer with the 130 gr. bullet and the 25-06 kills deer with the 120 gr. bullet then the 150 in the '06 ought to be up to the task as well. However, I know that some bullet weights suit some calibers better than others. I've been told that, in general, the '06 prefers the 150 gr. bullet over all others. Maybe there's some truth to that and perhaps its just an old hunter's tale.