My experience, while somewhat limited, is that as you test different powder charges, the groups open and tighten like bellows, until you find the accuracy load. The innumerable variables regarding pressure, barrel vibrations, condition of the bore, all have an effect on accuracy. I generally start about 8% below max, then work up in half-grain increments. Groups tended to open and close with each load, until they suddenly tightened, and my testing ended. Any pressure signs also shut down further upward development, naturally. Hope this helps.
PJ