The most common reason to have the sprue up is so you can visually affirm it is centered. If you place the sprue down, out of sight, the ball can easily slip to one side or another and the sprue won't be centered.
The need to center the sprue is controversial. Some claim that the little nubbin will affect the gyroscopic stability of the ball. Others claim it makes no difference. Test yourself and decide.
I place the sprue up, centered, out of habit. Been doing it that way for over 30 years. I'm too old, grumpy and set in my ways to have some whippersnapper tell me otherwise ... :evil: