You might want to check how deep the un-fired cartridge is sitting the the breech and then check how the once-fired brass sits in the breech. I have a 30/06 pistol barrel that I believe the chamber was cut a bit too deep. When using brand new brass, the case will sit approx. .002" below the breech (no good!). I do get the occasional misfire when using brass that is brand new. Once-fired brass from this barrel protrudes about .003" from the breech. My barrel to frame gap is about .003", so I size my case to protrude .002" from the breech and have no misfires. The misfires were driving me nuts until I figured out what the problem was. If you don't hand load, I don't know what to tell you, but if you do, I would fire form about 100 cases or so and use them for hunting. If your cases do sit too low in the breech and you don't hand load, send the barrel back to T/C.
I hope this helps. Let us know how you make out!