Mick & Jerry,
This is probably the most asked question in the Predator and Varmint forum. I don' think that there is a one answer- answer. You need enough bullet speed to get to the target, But not enough to not blow things all to smithereens. I have used every bullet that i could find, Some work up close and some work out there at a long distance. I have had pretty good luck with CALHOON bullets with every thing from my 17s to the 22-250s.
Had great luck with them in my 222s & 223s. If some one comes up with the DO IT ALL bullet i wish they would let me know. I have been fighting this battle for fifty five years and don't have a clue.
Good luck guys..........Joe..........