GB:
Nothing specific yet, but elk, bison and African plains game are in my cloud of ambitions. I handled the iron-sighted Winchester model 70 safari in 375 and it was love at first sight. The weight isn't bad for me. I figure that, loaded, it's only about a pound heavier than my 270. If there's something comparable with iron sights, the heavier weight, and in stainless/synthetic I'd be interested in it.
(Yes, I know a 300 or 375 will serve for these applications, but the choice of 375 in a heavier rifle is a matter of taste in this case.)