With the standard .22-250 you will get a max. point blank range of about 315 trds. , plus or minus. With the AI you will get about another 10 yrds., 15 max. You will burn alot more powder than you will gain in velosity, or range. If your looking for a wildcat that will reach out and touch them to these same yardages, and do it with less powder why not go with a .17 or a .20 round. I`ve got a .17 AH that pushes a 19 grn. bullet to 3600 fps. and shoots point blank to 290 yrds. with 10.4 grns. of powder. A good .17 Rem. will shoot with the .22-250 AI, and it`s a factory round. My next project, and I think the best long range round for varmints, is going to be a .20 BR. The new .204 Ruger should shoot with, or alittle better than the .22-250 AI, and the .20 BR should really put it on the .204. I do some strange things though, my smallest wildcat round is a .17 AH and my largest is a .411 Hawk, maybe you don`t want to play with the stuff alittle father out.