I suppose there is alot of options here to pick: and every situation has its own "most dangerous game".
If your on a REALLY high tree, then your probebly safe to hunt elephants but you have to watch out for tigers being on that tree lol.
I heard tigers are some of the most dangerous things to hunt, even if you shoot em in the heart, they can still charge at you for another 45 seconds to 1 minute, damn that enough time for it to kill me and anyone else with me.
Question, while dangerous game hunting, are MOST shots aimed at the brain ? shoulder ? heart ? gut (doubt it) ? or anywhere the cross hairs aim