I believe it's doable but the 22-250 or even better yet, the .243 would be a better choice. The salesman who sold me my .223 UV said he killed a yote at over 500yds with his, but he's a salesman. :-) I compared the ballistics of the 50gr accutip in 22-250 and .223 rem, at 500yds the .223 has 273ft/lbs energy compared to 372ft/lbs for the 22-250. Their long range drop chart didn't have the same zero for them, the 223 was a 200yd zero and had 45" of drop at 500yds, the 22-250 had a 250yd zero and 30" of drop at 500yds. I think if most of my yote shootin was at over 300yds, I'd choose a .243, .270, .280, 7mm-08 or .25-06 as the best tool in Handi calibers.
PS, maybe GB will move these posts to the NEF Centerfire forum?