I think I've got all the typical centerfire calibres in the Marlin safe, 218 Bee on up to 45-70. Guess I don't have a 450, nor plans for one, ditto the 480. The most used one of the bunch is my '78 vintage 444. It's taken elk, mulie, white-tail, antelope (why not, most of mine are shot well inside 150 yards), one moose, and about all the small stuff from coyote, fox, badger, praire dogs, etc. Used the Sierra 180's on the sod pups, boy did they ever expand! Haven't taken a bobcat with it, but with cast round balls it's done most of the small game too. Just for grins and giggles, it's also taken a few birds with shot loads, out to 20 yards, not too far off a 410 if you're luck is in. My vote goes for the .444 as my most used meat getter. Normally use either the old style Barnes 270's (getting low on these though), the old style Barnes 300 gr., paperpatch cast, or the Lee 310 gr. slug as cast and checked. All work just fine over a full case of 4198.