I use a 300 grain WFN with gascheck, cast of WW metal it runs about 310 grains, water drop the bullets out of the mould and lube with LBT Blue, 21.5 grains of H110 gives me 1425 out of my 6.5 inch 629 classic, but that gun runs fast because same load gives me 1375 out of 8 inch Dan Wesson 744. Load is a handful out of the 629 but not too bad in Big Dan. Shoots 4 inch groups at 100 off the bench all day long with 2X scope in 629, 3 inch out of Dan with 4x scope. Dan is way to big to drag to deer woods though.
For less flash and bang, 20 grains H110 goes 1250 in 629 and 1200 in Dan Wesson, shoots pretty much same groups as faster loads.