Hello,
.45 Colt your choice of the word zippy is more appropriatly used with the .44Magnum, in the 50s & 60s experiemnters used 170gn-180gn bullets zipping along at almost 2000fps (speed kills!) as did Super-Vel in the 70s.
The .45 Colt doesn't like the lighter faster bullets but with 250s up to 340s (I'm saving the 420gn story for another thread) the Colt comes into it's own special place.
HCLIFF? Somewhere online and in a past issue of American Handgunner Ross Siefried wrote about his preference to the .45 Colt brass over the 454 Casull brass in Five Shot High Pressure Designed Platforms.
Brass life from any brand Long Colt is contingent on Chamber size, Not Pressures.
SingleFan-
The S&W 625-7 is best fed Slow Burning Powders for optimum Safe Performance (re-Linebaugh, Siefried, etc) which leaves us with
WW-296 or H-110 (AVOID Lil Gun, recall in progress!!)
I've seen a few of the 625-7s-8s & 9s with a tad more endshake than need be fresh from the factory, shim kits are cheap from Brownells
Excess endshake is tough on guns especially with the heavy loads, shim to zero and no wear will occur.
Using a premium hardcast like the 280gn Bear Tooth mentioned start at 21.5gns H-110/WW296
Use a good chonograph and work up normally watching group size and velocity. 1200fps is plenty for the Bear Tooth but if 1250fps happens to be the "sweet spot" your safety window is beyond 1350fps with 300s
SingleFan, these loads have been tested using a five inch barrel so your results may vary etc.
My most used plinker load is 10gns of Unique with any available quality bullet from 250gn to 340gn
AA-5 is a very spikey fast burner I've reserved for autoloaders for plinking, it might be good for cowboy level loads.
Again, the new generation Smiths chambered in .45 Colt are significantly stronger than many other guns chambered in .45 Colt,
IMO it's the finest revolver available to the experienced handloader for both hunting and target work.