One T/C newbie to another:
If you like the .45 caliber so much, and have the access to reloading for it, as mentioned above, you may want to consider the .454. Most of the disadvantage to the .45 Colt/410 barrel (as I see it) is the amount of freebore because of the 410 chambering. I think, and I am by no means a qualified expert, that accuracy would be better out of a single caliber/cartridge barrel. And "cowboy" level loads are a hoot to practice with, that I know!
I recently got a Contender with four barrels, two of them I took right out for pistol familiarization - .44 Mag and .222 Rem. Shooting the .44 Mag with factory ammunition was entirely too hard to start out with, and I could not even think of developing a good hold. It was just to much out of a 10" Octagon barrel (fairly light). The .222 Rem was also a 10" Oct, but easier to control and didn't beat me up so much.
After going back to the computer and doing a slew of reading, I decided to follow the practice of getting a barrel I can shoot and have fun with, firstly to develope good shooting practices with the pistol, secondly to get totaly familiar and comfortable with it, lastly, be successful hitting the target where I want to.
I traded off the .222 Rem and a .357 Herret barrel, and got a 12" .22 Hornet bull barrel and a forend, and alot of advice and instruction on the disassembly and inner workings of the pistol. The Hornet is a cartridge I know I will be able to control, developing the familiarity I want, and be useful as a small game/varmint caliber. My aim is too work up to a 7-30 Waters for this pistol for hunting of all sorts.
Check out this article
http://www.handgunhunt.com/feature/s30/index.html, and then take a look at the others on this site, I found the information there made entirely TOO MUCH sense!
Good luck!