Gallahad,
I am shooting the Lyman 358429 which weighs in at 170+ grains and I am using .5 grain over the listed maximum charge in a Hodgdon manual. Regardless, I am getting average 1247 fps from a 6" Security-Six Ruger. You could PROBABLY start with 170 grain starting loads, but be careful as this H-110 doesn't like to be reduced much, or at least that is what it is advertised to be. I posted to just give you an idea of velocity of bullets in that weight range and H-110 powder. Good-luck...BCB