Well, they will obviously both do the job at typical "woods" hunting ranges. Where the 45/70 will have the advantage is at any kind of extended range, being that the BC is very high on most of the bullets available. This means the bulllet doesn't slow down as fast. The typical 12ga sabot slugs have terrible BC's so they slow down and lose energy really quick. The other advantage of the 45/70 is that it can be handloaded to much higher velocities than you could ever push a shotgun slug. I suscpect that accuracy is probably much more inherent also with the 45/70, than with a saboted slug, although I don't have a "scientific" explanation for that.