A handgun scope has a very small field of view as compaired to a rifle scope and it`s alot harder to find your target with one, there for the lowest power that will get the job done. I also am a Leupold fan. I bought 2 Burrius handgun scopes, a 1 x 4 and a 3 x 9. With the 3 x 9 the point of impact would move over 6 in. at 80 yrds. when change from 3x to 9x. I sold it. I mounted the 1 x 4 on my .500 S&W and it did not have enough adjustment to get it zeroed. I may try it on my .454, but if it doesn`t work there it will also be sold.
As for the veriables they are nice, but they are also alot larger and heaver than the fixed power scopes. I want to pick up a 1 x 4X variable power for my .500, it`s already heaver than I want to carry while walking. so I will use it for stand hunting only. I`ll be carring a .454 while walking and it wears a 2x scope.
If your just getting started useing a handgun scope definately get a 2x to start. And other thing, when useing a scoped handgun always shoot with both eyes open. focuse on your target with both eyes and then bring the gun down on the target. When the scope is right the target will pop into the scope. If you shot with 1 eye and look through the scope you`ll find yourself searching all over for the target.