The new Vaqueros are available now, in the larger stores. Smaller stores won't get their allotments until April, in some cases I know of. Going price seems to be in the $420 range around Portland, OR, about $40 more than the old Vaqueros sell for around here. 45 Colt seems to be the only available chambering around here.
Do not use the heavy loads listed for Ruger handguns in the new 45 Colt Vaqueros. The cylinders apparently have thinner walls, and will not tolerate those +P loads like the old Rugers built on the big Blackhawk frame. I have not yet measured the cylinders myself, but playing it safe sounds like a good idea.