Vlad, since the 22-250 and the .223 share bore size and twist rate, I would recommend bullets weighing less than 55gr which most .223 handis shoot extremely well. There has been only a post or 2 on the 22-250 that I can remember here since it was recently reintroduced, so there aren't many 22-250 handi shooter here. FWIW, there are a bunch of members at Predatormasters than love their Handis and Ultras for long range predator and varmint shooting, mostly in .223, but some 22-250 and 204 rugers.