Different powder LOTS explain the difference in velocity between H110 and WW296.
One lot of H110 may be faster than one lot of WW296 & vice versa.
In my area, H110 is about $2/lb cheaper than WW296.
For big bores, one needs only ONE powder, and that IS H110 !
For those that want less velocity, recoil, and muzzle blast than H110 provides in magnum cartridges:
Use a non-magnum PIP-SQUEAK cartridge.
I think the weakest worthwhile handgun cartridge for ANYTHING is the .45ACP in +P or HOTTER format.
Usually I choose something HOTTER such as the full-power 10mm or a HOT 357 mag for defensive purposes.