Wouldn't the 375 JDJ be a clear winner , better bullet choice ( spitzer type) , better trajectory ( longer range), proven record, it has killed everything from deer to elephant, real good case life , I didn't check specs but I would think higher velocity and more ft. pds. of energy.The 220 GR.hornaday for deer size game and the 270 gr. hornaday for elk size. With my 12 1/2 '' and magna port its very managable to shoot.