turk1.
The 243 Handi das a 1-10 twist (supposed) which will stabilize any .243 bullet up to 105gr. I say stabilize that does not mean the bullet will shoot with accuracy.
Unless you have a greatly oversize barrel or a twist less than 1-10". there is very little chance a bullet will keyhole.
With a 100 gr bullet you should be well off with H4841. With 39.0gr. of that powder your Handi should work without any hicups. Two grains more for 80gr bullets.
Stick with full sizing only, with the die adjusted to produce no more than .003" head space. Watch for the notorious 243 neck thickning and case stretching. This will kill accuracy for sure.