NEF says NO. I have read, somewhere on this site, that the SB2 10ga frame is still considered a SHOTGUN frame even though it is designated SB2. They had to change the designation because it has been altered enough to accomodate the larger diameter 10ga barrel. If I remember, they said that the receiver is still a shotgun receiver and not the stronger SB2 rifle receiver. There are those who know this stuff better than I, but if memory serves me, SB2-10ga is still a shotgun(just made larger for the 10ga barrel) and not a true SB2 rifle barrel. As Markus mentioned above, there could also be a problem with the firing pin alignment. The larger diameter of the Ultra 12ga barrel is why they use the SB2 10ga receiver. NEF says it is still made to shotgun specs and not rifle specs.
My thought, BETTER SAFE THAN SORRY. I would listen to NEF on this one.