I've taken 3 deer with my .357 Colt Python over the years. The only thing I shoot in it is 125gr JHP's infront of 13.5gr-16gr of Blue Dot. MV of 1500 to 1900fps depending on powder charge.
All 3 kills were close to 50yards away +/-, one was stopped dead in its tracks, the other two made it another 20-100ft before expiring.
Lucky shots maybe, but they worked. The slugs were completely fragmented, tearing up the entire chest cavity(heart and lunges). Contents were more mush than seperate orgins.
One thing I've learned, killing isn't an exact science. Animals have been hit with .22rf's and died instantly, and others of the same species hit with a .460 Weatherby Mag and live... go figure.
My .357 served me well, have since moved up to .44mag and retired the Python to target and show piece duty.