I have both the 22-250 and the 25-06.
Current experience is that the 22-250 barrel (in my opinion) was defective from the get-go. I think the chamber was drilled/reamed a little deep. Sent it back recently and have not received any word from T/C yet.
I have just started working up a load for the 25-06 barrel, but do know that the chamber is reamed properly, as compared to the 22-250.
In my opinion, in my brief time of ownership of the Encore, it appears to be a project weapon, in as much as the more you tinker with it, the better it shoots.
That, however is no different than ANY bolt action I owned either. Out of the box, all rifles I have owned shot a reasonable group.......but an unexceptable group TO ME.
My 22-250 barrel was shooting sub MOA groups with the first load I Plucked From the Air (PFA). Even though it had a headspace issue, it was much more capable from the get-go than my first Varmint rifle (Ruger heavy barrel M77).
Reloading for the single shot brings new challenges if you want minute of nail head accuracy. I expect that by the time I am done getting the various barrels I end up with shooting the way I want, I will be a true expert in the Encore field. Wouldn't have it any other way.
I have always been a crack shot and the rifle was merely an extension of my body. I don't feel that I could ever achieve the accuracy and ability I have shooting off-hand, sitting, bench rest, etc without paying the dues so to speak.
By the same token, in my prior life, I may be in a situation where I have to put a bullet to the left of a hostages ear to hit the bad guy in the brain stem....then use that same rifle (my rifle) hunting elk. Accuracy was not just a neat thing...it was an absolute necessity............. glad I no longer have to worry about such large issues.