I used to carry a detonics MKIV (boy..that's a blast from the past) in the pharmacy when I worked nights. I used 230gr win silvertips. I spoke with Mas Ayoob and John Farnam about this and they were pretty sure that any high quality 45ACP round would be effective in the 3" barrel as long as it fed. They said the velocity would never really be high enough to cause any huge expansion, but, the 45 cal wound channel would be sufficient for a stop. What I took away from the conversation was, reliability first, shootability second (as in can you hit what you need to under pressure), and sights, third, trigger, fourth and bullet last.
Just my opinion...
Regards,
Doug