I'm not saying it can't be done, bur rather it cannot be done well. I much prefer the H&H and Weatherby Magnums for this very reason. Unlike a lot of .300 Magnum shooters, I'm not particularly enthused about the higher velocities, unless I'm hunting elk in the mountains. I find a slower, heavier bullet much more deadly and far less likely to damage meat... and when it comes right down to it, I'm a meat hunter. I hunt to participate in the cycle of life and if there isn't any good meat to be had, the kill was simply the waste of a life. Okay, here's my schpiel... A 200 grain bullet has a sectional density factor of .301 which is preferable over a 180 grain bullet which is only .271. To punch hard enough at longer ranges one needs more initial momentum ie: mass and velocity and you need a heavier bullet to do it. Also, a 200 grain bullet has a better ballistic coefficient, mainly through its better sectional density rather than through form, and thus retains velocity better and the 200 grain bullet is ideal for the .300 Magnums. When the 220 grainers are used, velocity is lower and the flat trajectory is then compromised to some degree. However, if your hunting distance is more like 200 yards, the 220 grainer with a sectional density of .331 is even better yet. And you long range shooters should not overlook the benefit of simply zeroing in farther out.