I have large hands, N-Frame sized hands. I had a .22 LR version, and when I fired it, the gun would end up pointing straight up at the sky. There are larger "target" grips but by the time you put them on, you are in the size range of bigger, more accurate, more powerful guns.
My .22 Mag/.22LR version sits in the box, wearing the bigger target grips. In that configuration, I find I prefer to carry a Colt Mustang PocketLite .380.
If you buy one, may I suggest that you buy the .22 Mag/.22 LR version? If you decide to use it as a defensive pistol, the .22 Mag will put you in the same ballpark as a .380 in terms of power. Also, the .22 Mag grip frame is a little thicker than the .22 LR, and this difference may be enough to give some of you the grip you need to keep this pointed at the target.