My cousin who hunts coyotes with me uses I believe 55grain but may be 50 nosler ballistic tips. And as graybeard said except on very close shots haven't had an exit . Very accurate in his handi. As to the POI difference the only way to find out is to shoot the different loads in "Your gun" . There will almost without a doubt be a shift in POI between the loads you specified, how much waits to be seen . I have a .270 that will shoot 130 grain win. p.p. 1"@ 100 yd group all day, put any other brand ie: rem., fed. big difference. The win.'s patterned the best and I had the bruised shoulder to prove it, I tried many different loads, just shouldn't have done it in the same day.LOL
Good-Luck,
zapper :-)