I can tell you 2 loads that are very accurate in a wide variety of 45-70's. Both are with 350 gr bullets. If you want reduced recoil, dropping to the 350 gr helps a lot. Here goes-- 1st load--350 gr cast bullet, 14 grs of Unique, dacron poly filler over powder, Federal std primer. 2nd load--350 gr cast bullet, 15 grs of SR 7625, creme of wheat filler, Federal std primer. I can't emphasize enough not to deviate in the slightest on this data should you decided to try it and do so at your own risk. I have fired many hundreds of these loads in a half dozen reproduction Sharps with the only side effect-- accuracy.