ranger'
it drives some of the guys nuts, but i still say, if using a micro-grooved barrel go with a gas-checked projectile like in the picture above. that's the real secret in shooting 'tight' bullets in a micro-groove when using cast bullets. otherwise, try shooting jacketed projectiles, and stay away from Unique - in my opinion. it can be a very versatile powder, but not every firearm takes to Unique.
try IMR 4227, Alliant 2400, or bulk wc-820 for good results in the .44 mag' with a variety of bullet weights. Win' 296 and H-110 are generally for heavier bullets. a faster powder that Ed Matunas liked in the .44 mag' was Hi-Skor 800-X. he once wrote it up as part of an article in a Handloader's Digest. he got respectable velocities, and excellent accuracy with 800-X.
use a tight crimp, with brass that is uniformly trimmed for length to achieve a consistent result with your crimping.
tell us more when you get out with it again,
ss'