I have an Ohaus 10-10 and the stated accuracy is +/- .1
To answer your question, I have a Lyman DPS 1200 and I think its the greatest thing since bottled beer. When I first got it, I checked it against my 10-10 often. And it was right on.
The thing is, it doesn't meter the powder directly into the case but into a little pan. As it is metering the charge, the weight is shown on a readout. If, when it beeps (to show its done), if it isn't right on, you dump that charge back into the hopper and start over.
I would guess that its possible (probable) that the charge of say 27.0 could be 26.09 or 27.01 and register as 27 but I don't think that would make a difference. I've loaded for a lot of .223's and never had one where .1 gr of powder would have such the dramatic effect you outline. What does "opening up" mean in actual measurements??