Federal has a line of heavy cast bullets loaded to standard pressures. Can't remember what they're calling it, but I've seen them around locally. As long as you're using a good quality hunting bullet, any standard pressure 45 Colt load will kill a deer at 50 yards. Look for hardcast lead flatpoint or jacketed soft point bullets. As always, no bullet or load will kill an animal cleanly if you make a bad shot. Practice untill you can put every bullet into a 6" circle offhand at 50 yards. If you don't reload, it'll cost you a bundle, but PRACTICE, PRACTICE, PRACTICE.