Finally got some reloads made up and shot the new 500 S&W barrel. 400 gr. cast bullet over 35 gr. of H110, WLR primer, Starline brass. Just shot enough to get the scope on target, and one group of three. Group was about an inch at 50 yds. Noise was off the scale, recoil was stout, but manageable. I cannot imagine shooting one of these in a handgun. I believe that is more fun than I would ever want to have! Those big holes look impressive in a sheet of paper, I just hope they look as impressive in a deer.