straight-shooter-x: you have to look for a couple of things. (1) turn the revolver towards you and look to see that the cylinder crane (the part that swings the cylinder out) fits flush with the the frame. If there is any spacing between the crane and the frame you revolver may have seen pressures at teh upper limits, or beyond.
(2) cycle the action slowly by pulling the hammer back to a full cock position, very slowly, for two full revolutions of the cylinder. Check to see that the cylinder stop properly seats in the cylinder notches, either just as or just before the hammer goes into full cock. If it does this on all 6 chambers, twice, it's good. If the cylinder stop does not properly index at full cock, your advancing hand may need replacement. If you thumb the hammer back with any degree of force or speed and the cylinder stop indexes properly, but not when done slowly, you may need to replace that 'hand'.
(3) check for any loose sights. (4) check for lead rings in the chambers, which would indicate that cases shorter than full length factory ammo have been used (ie, 44 Spl in 44 mag chambers) and may prevent full length cartridge chambering.
(5) use a wooden dowl the size of the bullet to assure that the barrel and individual chambers line up properly so that you don't experience bullet shaving (6) use a bore light to check the barrel for copper or lead fouling. (7) cycle the action to check for any binding.
Hope this helps. Good luck. Mikey.