It has been my experience that with most rounds, the best accuracy occurs when the case is full, or close to full. I haven't tried the H4381 as IMR4381 works good in my .243 as well. Plus, Dupont has a race car on the track.... I would suspect that H4381 would fill the case a little better than IMR4381 and would think that H4381 would be most excellent!
With all the powders available, and the fact a fellow has to buy a pound at a time, and having had powders that just didn't work for me for different reasons, a dual purpose powder is a plus for me.......
I haven't' started reloading for the 45.70 and .35 Remington, but hope to find one powder that works well for both.......I've posted about this in the past and have gotten several suggestions......
I really wish that IMR Dupont, Hogdens, Winchester, and the others would market a "sampler" pack with a couple of ounces of there best........maybe an 8 pack of the best sellers......sure would make load development cheaper! I know I've loaded up 30 or forty rounds with one type powder and knew within 10 minutes it didn't suit me.......then I'm stuck with $18 to $20 dollars worth of powder I won't ever use again.........