I have killed several deer with them, worked like a charm inside of 175 yards. I shot a deer at 242 yards in the shoulder and the bullet did not penetrate through the rib cage. I know some people will say that it was the shot fault not the bullet, but that is the shot I like to take. I imagine it would have still done its job just behind the shoulder.
I do know that a Barnes X or a Hornady SST will do the job out to 300 yards through the shoulder.