Sorry to disagree Zachary, but an old friend who owns a cattle farm has put down several yotes with his .22lr. Again, he's an old Tennessee farm boy that grew up with a rifle in his hands and shooting it is second nature to him.....I myself have killed a couple with the lowley little .22lr........we both laugh at the magnumitisus that's spreading around the country..........can't kill a yote with a .22.......can't kill a deer with a 30-30.......or can't kill a deer with a .243........
As for the scope, a nikon prostaff fixed 4X would be my choice as 100 yards is really the limit for "practical" shooting.