A man's got to know his limitations
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Thats why my SRH is a 480 and not a 454! It is also why I don't own a 475 or 500, I've shot them, but I can' handle that level of recoil, I don't need highpower misses
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The 480 doesn't have the harsh recoil of the 454, it has the same feel as a 44, but on a bigger scale :-D
The upside of the 454 is it can be downloaded to do anything the 44 does. Just because your gun is capable of tremendous levels of power, doesn't mean you need to shoot it at that level. The majority of my 480 rounds are 310 gr cast over 9.7 gr unique for 950 fps.
If your second knuckle was getting smashed by the triggerguard, you can put on Hogue grips, which put your grip lower on the frame. But, beware, the muzzle whip will be greatly enhanced.