I used a Leupold 3 - 9X on my South Africa trip for my .375 H&H Mag. and it worked well. I had it set on 9X the whole time. On the one 200 yard shot I took, I was glad for the magnification and it wasn't too much magnification for the 80 to 100 yard shots. I was after plains game and not dangerous game. If I had be hunting dangerous game, I probably would have preferred something with a little less magnification.
The one thing you want to be sure to have is enough eye relief. My scope is on an Encore and if I'm not careful, I get dinged in the forehead. A muzzel brake would solve this problem but I prefer no muzzel brake.