I have had about 12 Ruger .45s and all have been undersized. Some have been worse than others: Chamber throats varying in diameter, or slightly oval or S shaped. All kinds of interesting shapes, but not cylindrical. I broke down and bought a reamer myself. Reaming will usually clean up the imperfections and inconsistency. I have cleaned up all of them. Each of them benefited from the work.
That isnt the end of the work, though. Because the barrel is choked as it is overtorqued when fitted, you can cut out some extra metal, or firelap the barrel to make the barrel true. They usually need the forcing cone cleaned up. I have the 11 degree cutter for .44 and .45 and the 5 degree cutter for .38. I just redid a .357 last week and it really helped it.
That said, the .44 Super Blackhawk I got last year was spot on. The cylinder throats were .431 and the forcing cone was beautiful. It shot great from the beginning and is just as tight now as it was then.