I loaded for 3 .22-250's, and 2 of them liked Hornady's 52g HPBT, and the other one liked a 50g Vmax best. Varget worked best for 2 rifles, and the other prefered IMR 4064. The 52 grainers traveled around 3600 fps, and the 50g V-Max was up around 3700 fps. Accuracy for all 3 rifles was well under the inch at 100 yards.