I shoot 160 grain Speer Grand Slams religiously.... because we had a great supply of cheap factory seconds, which has just dried up.
This bullet pushed at about 2500 fps by 44 grains of IMR 4350 is all I use. It works on everything, is cheap to run, doesn't kick, and shoots flatter than trajectory nerds would believe. Sighted two inches high at 100 yards I am real confident out to 300 yards and I have only ever fired at fur that far twice, once 320 Elk, and 298 coyote.
The rest have all been under 2 hundred yards.
This year's white-tail at 110yards was a one shot affair (details on deer hunting page), and the butcher asked me what I was using because, in his words, "It must be a big gun, there was no blood shooting near the entrance hole but inside there was all kinds of trauma, and the exit hole was about two inches with some bone carried away." He just shook his head when I smiled and handed him a round.
Slow speed, lightning kills, take that velocity pimps.