Depends on for what purpose, as a general purpose hunting gun for sport, or as a survival gun to feed you and your family, with the abilty to carry enough ammo to feed them for a long time? For sport hunting, I'd take the 12 gauge 30-06 combo, not much you can't do, or kill with it. But if I had to survive, and eat and feed my family daily, it would be a Savage 24 Camper in 22 rimfire over 20 gauge configuration. One can carry a lot of ammo in a small amount of space, and an old poacher I knew from up New York state many years ago told me that 'big pieces of red meat drop on the spot when hit in the right place with a 40 grain bullet'. And when you consider that shot placement is whats it's all about, he was absolutely right.
Sincerely,
Garry