The 280 can shoot reduced loads quite effectively, I was concerned about recoil for my daughter who is a beginning shooter and is fairly lighlty built.
My thought was if I could come up with a load that duplicated my 7x30 water 14" it would work well.
35 gr of IMR4198 with a 120 Nosler BT overall lenght 3.29 conistently puts three shots into .75 or less at 100 yds, from a 22" rem mtn rifle.
My daughter shot a nice 4x4 whitetail at 150 yds down hill angling towards us, struck him at the base of the neck and angled down into the chest cavity, dumped him right there, bullet expansion was good and penetrated well.