I long ago lost count of the number of deer that I and my friends have taken with the .44 mag. ammo that I loaded. What I loaded was abt. 1,250 fps with a 240 gr. bullet. I tried alot of diffeerent bullets and found that I got the best in accuracy and terminal performance with the Serria bullet. At 1,250 the Hornadys do not expand, but they are very accurate. With the Serria bullets the only 1 I ever recovered was from a 10 point buck shot at 135 yrds. while 1/4 away from me. I shot him in the left rear and recovered the bullet just under the skin of the frount shoulder. It had mushroomed perfectly and still had over 95% of it weight. I tried some 180 gr. Serrias once, I got a deer, but the first shot at abt. 10 yrds. left an entrence hole like a 16 oz. water glass but did not get to the heart. A second through the ribs did the job, but I would not recomand the liter Serria bullets. Hornady puts heaver jacket on their bullets and you might be able to use their lite bullets on deer. For the last 25 yrs. or so my .44 mag. deer load is a max. charge of Win. 296 powder and a 240 gr. Serria bullet.