Sure have,I have a pretty accurate remington 700 in 22-250 that I worked up loads with every rifle powder I've had onhand over the years.Found that most would match or come close to my all time favorite load with Imr 3031 over 50-55 gr sierras.The ww748 load I used was 35grs under a 55gr sierra and would give half inch groups if I did my part.Now that is a mild load but still went right at 3400fps and did fine on groundhogs.So I would work up a load and use it and it will do fine.