The only experience that I have is being with my son when he shot a moose with a 150 gr sirocco at 150 yd with his 7mm mag, about the same as the 280, the bullet did a good job, nice mushroom and good retention. Did not exit, liver shot, killed the moose. Relating to deer, again, I was with him when he shot a 205lb whitail at 403 long paces with a sierra 140 gr bt gameking that I re-loaded with H4831. The bullet performed well, no exit, I removed the heart in 3 pieces. I am not promoting either one, just my experiences with 140=150 gr bullets in two seperate and different applications, hope this helps.