Like all things in life there is a trade off. You get the convienence of a Takedown, but it comes at the price of more wear with a steady diet of any loads. It also will wear each time you actually "take down" the rifle. The wear will depend on many factors such as quality of the takedown, quality of the metal, preasure of the loads, care in handling etc. But overall a non takedown of the same quality and care will outlast a similar rifle of the takedown configuration. How much difference is impossible to say?